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Maintenance of pluripotency in mouse ES cells without Trp53

Tumor suppressor Trp53 works as a guardian of the genome in somatic cells. In mouse embryonic stem (ES) cells, it was reported that Trp53 represses pluripotency-associated transcription factor Nanog to induce differentiation. However, since Trp53-null mice develop to term, Trp53 is dispensable for b...

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Detalles Bibliográficos
Autores principales:	Shigeta, Masaki, Ohtsuka, Satoshi, Nishikawa-Torikai, Satomi, Yamane, Mariko, Fujii, Setsuko, Murakami, Kazuhiro, Niwa, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796736/ https://www.ncbi.nlm.nih.gov/pubmed/24126347 http://dx.doi.org/10.1038/srep02944

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