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Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain. Our previous computational studies proposed a model stating that a properly assembled nonlinear motif termed the Regulatory (R) spine is essen...

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Detalles Bibliográficos
Autores principales: Meharena, Hiruy S., Chang, Philip, Keshwani, Malik M., Oruganty, Krishnadev, Nene, Aishwarya K., Kannan, Natarajan, Taylor, Susan S., Kornev, Alexandr P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797032/
https://www.ncbi.nlm.nih.gov/pubmed/24143133
http://dx.doi.org/10.1371/journal.pbio.1001680