‘Clustering’ SIRPα into the Plasma Membrane Lipid Microdomains Is Required for Activated Monocytes and Macrophages to Mediate Effective Cell Surface Interactions with CD47

SIRPα, an ITIMs-containing signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain unclear. Here we report that while the purified SIRPα binds t...

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Detalles Bibliográficos
Autores principales: Ha, Binh, Lv, Zhiyuan, Bian, Zhen, Zhang, Xiugen, Mishra, Aarti, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797048/
https://www.ncbi.nlm.nih.gov/pubmed/24143245
http://dx.doi.org/10.1371/journal.pone.0077615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797048/
https://www.ncbi.nlm.nih.gov/pubmed/24143245
http://dx.doi.org/10.1371/journal.pone.0077615

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