Activation Associated ERK1/2 Signaling Impairments in CD8(+) T Cells Co-Localize with Blunted Polyclonal and HIV-1 Specific Effector Functions in Early Untreated HIV-1 Infection

We recently observed that a large proportion of activated (CD38(+)HLA-DR(+)) CD8(+) T cells from recently HIV-1-infected adults are refractory to phosphorylation of ERK1/2 kinases (p-ERK1/2-refractory). Given that the ERK1/2 pathway mediates intracellular signaling critical for multiple T cell funct...

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Detalles Bibliográficos
Autores principales: Crawford, Timothy Q., Hecht, Fredrick M., Pilcher, Christopher D., Ndhlovu, Lishomwa C., Barbour, Jason D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797111/
https://www.ncbi.nlm.nih.gov/pubmed/24143233
http://dx.doi.org/10.1371/journal.pone.0077412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797111/
https://www.ncbi.nlm.nih.gov/pubmed/24143233
http://dx.doi.org/10.1371/journal.pone.0077412

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