IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis

Interleukin (IL)-32 is known to exert adujvant effects on innate immune response, however, receptors and downstream signaling pathways remain to be clarified. Here we found that IL-32γ upregulated serine protease activity of proteinase-3 (PR3), in turn triggering protease-activated receptor 2 (PAR2)...

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Detalles Bibliográficos
Autores principales: Nakayama, Masanori, Niki, Yasuo, Kawasaki, Toshiki, Takeda, Yuki, Ikegami, Hiroyasu, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797434/
https://www.ncbi.nlm.nih.gov/pubmed/24129891
http://dx.doi.org/10.1038/srep02960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797434/
https://www.ncbi.nlm.nih.gov/pubmed/24129891
http://dx.doi.org/10.1038/srep02960

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