Molecular Dynamic Simulation Reveals Damaging Impact of RAC1 F28L Mutation in the Switch I Region

Ras-related C3 botulinum toxin substrate 1 (RAC1) is a plasma membrane-associated small GTPase which cycles between the active GTP-bound and inactive GDP-bound states. There is wide range of evidences indicating its active participation in inducing cancer-associated phenotypes. RAC1 F28L mutation (R...

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Detalles Bibliográficos
Autores principales: Kumar, Ambuj, Rajendran, Vidya, Sethumadhavan, Rao, Purohit, Rituraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797686/
https://www.ncbi.nlm.nih.gov/pubmed/24146998
http://dx.doi.org/10.1371/journal.pone.0077453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797686/
https://www.ncbi.nlm.nih.gov/pubmed/24146998
http://dx.doi.org/10.1371/journal.pone.0077453

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