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Targeted Gene Deletion of miRNAs in Mice by TALEN System

Mice are among the most valuable model animal species with an enormous amount of heritage in genetic modification studies. However, targeting genes in mice is sometimes difficult, especially for small genes, such as microRNAs (miRNAs) and targeting genes in repeat sequences. Here we optimized the ap...

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Detalles Bibliográficos
Autores principales: Takada, Shuji, Sato, Tempei, Ito, Yoshiaki, Yamashita, Satoshi, Kato, Tomoko, Kawasumi, Miyuri, Kanai-Azuma, Masami, Igarashi, Arisa, Kato, Tomomi, Tamano, Moe, Asahara, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797721/
https://www.ncbi.nlm.nih.gov/pubmed/24146809
http://dx.doi.org/10.1371/journal.pone.0076004