Dolutegravir Interactions with HIV-1 Integrase-DNA: Structural Rationale for Drug Resistance and Dissociation Kinetics

Signature HIV-1 integrase mutations associated with clinical raltegravir resistance involve 1 of 3 primary genetic pathways, Y143C/R, Q148H/K/R and N155H, the latter 2 of which confer cross-resistance to elvitegravir. In accord with clinical findings, in vitro drug resistance profiling studies with...

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Detalles Bibliográficos
Autores principales: DeAnda, Felix, Hightower, Kendra E., Nolte, Robert T., Hattori, Kazunari, Yoshinaga, Tomokazu, Kawasuji, Takashi, Underwood, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797783/
https://www.ncbi.nlm.nih.gov/pubmed/24146996
http://dx.doi.org/10.1371/journal.pone.0077448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797783/
https://www.ncbi.nlm.nih.gov/pubmed/24146996
http://dx.doi.org/10.1371/journal.pone.0077448

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