Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

Cells exposed to ER-stress undergo the Unfolded Protein Response (UPR) to avoid apoptosis, but may also activate autophagy. However, the signal for selection of one of these two protective responses is unknown. To clarify the key switch between autophagy and apoptosis, we examined the correlation of...

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Detalles Bibliográficos
Autores principales: Matsumoto, Hiroki, Miyazaki, Shuichi, Matsuyama, Satoshi, Takeda, Masayuki, Kawano, Makoto, Nakagawa, Hiroshi, Nishimura, Kazuhiko, Matsuo, Saburo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798192/
https://www.ncbi.nlm.nih.gov/pubmed/24167719
http://dx.doi.org/10.1242/bio.20135033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798192/
https://www.ncbi.nlm.nih.gov/pubmed/24167719
http://dx.doi.org/10.1242/bio.20135033

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