The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner

TUSC2-defective gene expression is detected in the majority of lung cancers and is associated with worse overall survival. We analyzed the effects of TUSC2 re-expression on tumor cell sensitivity to the AKT inhibitor, MK2206, and explored their mutual signaling connections, in vitro and in vivo. TUS...

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Detalles Bibliográficos
Autores principales: Meng, Jieru, Majidi, Mourad, Fang, Bingliang, Ji, Lin, Bekele, B. Nebiyou, Minna, John D., Roth, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798310/
https://www.ncbi.nlm.nih.gov/pubmed/24146957
http://dx.doi.org/10.1371/journal.pone.0077067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798310/
https://www.ncbi.nlm.nih.gov/pubmed/24146957
http://dx.doi.org/10.1371/journal.pone.0077067

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