Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Latency-associated nuclear antigen (LANA) mediates γ2-herpesvirus genome persistence and regulates transcription. We describe the crystal structure of the murine gammaherpesvirus-68 LANA C-terminal domain at 2.2 Å resolution. The structure reveals an alpha-beta fold that assembles as a dimer, remini...

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Detalles Bibliográficos
Autores principales: Correia, Bruno, Cerqueira, Sofia A., Beauchemin, Chantal, Pires de Miranda, Marta, Li, Shijun, Ponnusamy, Rajesh, Rodrigues, Lénia, Schneider, Thomas R., Carrondo, Maria A., Kaye, Kenneth M., Simas, J. Pedro, McVey, Colin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798461/
https://www.ncbi.nlm.nih.gov/pubmed/24146618
http://dx.doi.org/10.1371/journal.ppat.1003673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798461/
https://www.ncbi.nlm.nih.gov/pubmed/24146618
http://dx.doi.org/10.1371/journal.ppat.1003673

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