γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate

BACKGROUND: γ-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. The modulation of GGH may therefore affect chemosensitivity of cancer cells, and exogenous folate levels may further modify thi...

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Detalles Bibliográficos
Autores principales: Kim, S-E, Cole, P D, Cho, R C, Ly, A, Ishiguro, L, Sohn, K-J, Croxford, R, Kamen, B A, Kim, Y-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798974/
https://www.ncbi.nlm.nih.gov/pubmed/24045662
http://dx.doi.org/10.1038/bjc.2013.579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798974/
https://www.ncbi.nlm.nih.gov/pubmed/24045662
http://dx.doi.org/10.1038/bjc.2013.579

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