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γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate

BACKGROUND: γ-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. The modulation of GGH may therefore affect chemosensitivity of cancer cells, and exogenous folate levels may further modify thi...

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Detalles Bibliográficos
Autores principales:	Kim, S-E, Cole, P D, Cho, R C, Ly, A, Ishiguro, L, Sohn, K-J, Croxford, R, Kamen, B A, Kim, Y-I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798974/ https://www.ncbi.nlm.nih.gov/pubmed/24045662 http://dx.doi.org/10.1038/bjc.2013.579

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