Many disease-associated variants of hTERT retain high telomerase enzymatic activity

Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer. Understanding the molecular basis of these telomerase-associated diseases requires dependable quantitative measurements of...

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Detalles Bibliográficos
Autores principales: Zaug, Arthur J., Crary, Sharon M., Jesse Fioravanti, Matthew, Campbell, Kristina, Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799428/
https://www.ncbi.nlm.nih.gov/pubmed/23901009
http://dx.doi.org/10.1093/nar/gkt653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799428/
https://www.ncbi.nlm.nih.gov/pubmed/23901009
http://dx.doi.org/10.1093/nar/gkt653

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