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A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polµ and Polλ
Human DNA polymerases mu (Polµ) and lambda (Polλ) are X family members involved in the repair of double-strand breaks in DNA during non-homologous end joining. Crucial abilities of these enzymes include bridging of the two 3′ single-stranded overhangs and trans-polymerization using one 3′ end as pri...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799444/ https://www.ncbi.nlm.nih.gov/pubmed/23935073 http://dx.doi.org/10.1093/nar/gkt681 |