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A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polµ and Polλ

Human DNA polymerases mu (Polµ) and lambda (Polλ) are X family members involved in the repair of double-strand breaks in DNA during non-homologous end joining. Crucial abilities of these enzymes include bridging of the two 3′ single-stranded overhangs and trans-polymerization using one 3′ end as pri...

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Detalles Bibliográficos
Autores principales:	Martin, Maria Jose, Garcia-Ortiz, Maria Victoria, Gomez-Bedoya, Ana, Esteban, Veronica, Guerra, Susana, Blanco, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799444/ https://www.ncbi.nlm.nih.gov/pubmed/23935073 http://dx.doi.org/10.1093/nar/gkt681

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