In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

Gene-editing nucleases enable targeted modification of DNA sequences in living cells, thereby facilitating efficient knockout and precise editing of endogenous loci. Engineered nucleases also have the potential to introduce mutations at off-target sites of action. Such unintended alterations can con...

Descripción completa

Detalles Bibliográficos
Autores principales: Sander, Jeffry D., Ramirez, Cherie L., Linder, Samantha J., Pattanayak, Vikram, Shoresh, Noam, Ku, Manching, Foden, Jennifer A., Reyon, Deepak, Bernstein, Bradley E., Liu, David R., Joung, J. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799455/
https://www.ncbi.nlm.nih.gov/pubmed/23945932
http://dx.doi.org/10.1093/nar/gkt716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799455/
https://www.ncbi.nlm.nih.gov/pubmed/23945932
http://dx.doi.org/10.1093/nar/gkt716

Ejemplares similares