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The sequencing bias relaxed characteristics of Hi-C derived data and implications for chromatin 3D modeling
The 3D chromatin structure modeling by chromatin interactions derived from Hi-C experiments is significantly challenged by the intrinsic sequencing biases in these experiments. Conventional modeling methods only focus on the bias among different chromatin regions within the same experiment but negle...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799458/ https://www.ncbi.nlm.nih.gov/pubmed/23965308 http://dx.doi.org/10.1093/nar/gkt745 |