Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

DNA methylation is an important epigenetic mark in eukaryotes, and aberrant pattern of this modification is involved in numerous diseases such as cancers. Interestingly, DNA methylation is reversible and thus is considered a promising therapeutic target. Therefore, there is a need for identifying ne...

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Detalles Bibliográficos
Autores principales: Gros, Christina, Chauvigné, Laura, Poulet, Anaïs, Menon, Yoann, Ausseil, Frédéric, Dufau, Isabelle, Arimondo, Paola B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799459/
https://www.ncbi.nlm.nih.gov/pubmed/23980028
http://dx.doi.org/10.1093/nar/gkt753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799459/
https://www.ncbi.nlm.nih.gov/pubmed/23980028
http://dx.doi.org/10.1093/nar/gkt753

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