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Inhibition of cdk9 during Herpes Simplex Virus 1 Infection Impedes Viral Transcription
During herpes simplex virus 1 (HSV-1) infection there is a loss of the serine-2 phosphorylated form of RNA polymerase II (RNAP II) found in elongation complexes. This occurs in part because RNAP II undergoes ubiquitination and proteasomal degradation during times of highly active viral transcription...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799718/ https://www.ncbi.nlm.nih.gov/pubmed/24205359 http://dx.doi.org/10.1371/journal.pone.0079007 |