Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell populations and are highly resistant to standard chemotherapy. Here we demonstrate that metformin selectively ablated pancrea...

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Detalles Bibliográficos
Autores principales: Lonardo, Enza, Cioffi, Michele, Sancho, Patricia, Sanchez-Ripoll, Yolanda, Trabulo, Sara Maria, Dorado, Jorge, Balic, Anamaria, Hidalgo, Manuel, Heeschen, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799760/
https://www.ncbi.nlm.nih.gov/pubmed/24204632
http://dx.doi.org/10.1371/journal.pone.0076518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799760/
https://www.ncbi.nlm.nih.gov/pubmed/24204632
http://dx.doi.org/10.1371/journal.pone.0076518

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