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Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells
Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell populations and are highly resistant to standard chemotherapy. Here we demonstrate that metformin selectively ablated pancrea...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799760/ https://www.ncbi.nlm.nih.gov/pubmed/24204632 http://dx.doi.org/10.1371/journal.pone.0076518 |