Optimization of vaccine responses with an E1, E2b, E3 deleted Ad5 vector circumvents pre-existing anti-vector immunity

Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in preclinical models, but have muted responses in human trials due to wide spread pre-existing anti-adenovirus immunity. Attempts to circumvent Ad5 specific immunity by us...

Descripción completa

Detalles Bibliográficos
Autores principales: Osada, Takuya, Yang, Xiao Yi, Hartman, Zachary C., Glass, Oliver, Hodges, Bradley L., Niedzwiecki, Donna, Morse, Michael A., Lyerly, H. Kim, Amalfitano, Andrea, Clay, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800002/
https://www.ncbi.nlm.nih.gov/pubmed/19229288
http://dx.doi.org/10.1038/cgt.2009.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800002/
https://www.ncbi.nlm.nih.gov/pubmed/19229288
http://dx.doi.org/10.1038/cgt.2009.17

Ejemplares similares