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Optimization of vaccine responses with an E1, E2b, E3 deleted Ad5 vector circumvents pre-existing anti-vector immunity

Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in preclinical models, but have muted responses in human trials due to wide spread pre-existing anti-adenovirus immunity. Attempts to circumvent Ad5 specific immunity by us...

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Detalles Bibliográficos
Autores principales:	Osada, Takuya, Yang, Xiao Yi, Hartman, Zachary C., Glass, Oliver, Hodges, Bradley L., Niedzwiecki, Donna, Morse, Michael A., Lyerly, H. Kim, Amalfitano, Andrea, Clay, Timothy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800002/ https://www.ncbi.nlm.nih.gov/pubmed/19229288 http://dx.doi.org/10.1038/cgt.2009.17

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