Activation of GSK3β by Sirt2 Is Required for Early Lineage Commitment of Mouse Embryonic Stem Cell

Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization. However, its role in embryonic stem cells (ESCs) remains unclear. Here we demonstrate that Sirt2 is up-regulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Si, Xiaoxing, Chen, Wen, Guo, Xudong, Chen, Long, Wang, Guiying, Xu, Yanxin, Kang, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800056/
https://www.ncbi.nlm.nih.gov/pubmed/24204656
http://dx.doi.org/10.1371/journal.pone.0076699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800056/
https://www.ncbi.nlm.nih.gov/pubmed/24204656
http://dx.doi.org/10.1371/journal.pone.0076699

Ejemplares similares