Combination of LC3 shRNA Plasmid Transfection and Genistein Treatment Inhibited Autophagy and Increased Apoptosis in Malignant Neuroblastoma in Cell Culture and Animal Models

Malignant neuroblastoma is an extracranial solid tumor that usually occurs in children. Autophagy, which is a survival mechanism in many solid tumors including malignant neuroblastoma, deters the efficacy of conventional chemotherapeutic agents. To mimic starvation, we used 200 nM rapamycin that ind...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohan, Nishant, Chakrabarti, Mrinmay, Banik, Naren L., Ray, Swapan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800129/
https://www.ncbi.nlm.nih.gov/pubmed/24205354
http://dx.doi.org/10.1371/journal.pone.0078958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800129/
https://www.ncbi.nlm.nih.gov/pubmed/24205354
http://dx.doi.org/10.1371/journal.pone.0078958

Ejemplares similares