Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists

Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung, b...

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Detalles Bibliográficos
Autores principales: Vinader, Victoria, Ahmet, Djevdet S., Ahmed, Mohaned S., Patterson, Laurence H., Afarinkia, Kamyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800133/
https://www.ncbi.nlm.nih.gov/pubmed/24205302
http://dx.doi.org/10.1371/journal.pone.0078744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800133/
https://www.ncbi.nlm.nih.gov/pubmed/24205302
http://dx.doi.org/10.1371/journal.pone.0078744

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