Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′-enyl) acetonitrile (DT), was isolated from the sponge Pseudoceratina sp., and was found to exhibit a significant cytotoxic activity against leukemia K562 cells. Despite the large number of the isolated bro...

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Detalles Bibliográficos
Autores principales: Su, Jui-Hsin, Chen, Yu-Cheng, El-Shazly, Mohamed, Du, Ying-Chi, Su, Chiang-Wen, Tsao, Chia-Wei, Liu, Li-Lian, Chou, Yalan, Chang, Wen-Been, Su, Yin-Di, Chiang, Michael Y., Yeh, Yao-Tsung, Lu, Mei-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801119/
https://www.ncbi.nlm.nih.gov/pubmed/24065159
http://dx.doi.org/10.3390/md11093168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801119/
https://www.ncbi.nlm.nih.gov/pubmed/24065159
http://dx.doi.org/10.3390/md11093168

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