Diabetic Hyperglycemia activates CaMKII and Arrhythmias by O linked Glycosylation

Ca(2+)-Calmodulin dependent protein kinase II (CaMKII) is a regulatory node in heart and brain, and its chronic activation can be pathological. CaMKII activation seen in heart failure can directly induce pathological changes in ion channels, Ca(2+) handling and gene transcription.(1) Here we discove...

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Detalles Bibliográficos
Autores principales: Erickson, Jeffrey R., Pereira, Laetitia, Wang, Lianguo, Han, Guanghui, Ferguson, Amanda, Dao, Khanha, Copeland, Ronald J., Despa, Florin, Hart, Gerald W., Ripplinger, Crystal M., Bers, Donald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801227/
https://www.ncbi.nlm.nih.gov/pubmed/24077098
http://dx.doi.org/10.1038/nature12537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801227/
https://www.ncbi.nlm.nih.gov/pubmed/24077098
http://dx.doi.org/10.1038/nature12537

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