Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.

Detalles Bibliográficos
Autores principales: Engel, Mark, Sidwell, Tom, Vasanthakumar, Ajithkumar, Grigoriadis, George, Banerjee, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803129/
https://www.ncbi.nlm.nih.gov/pubmed/24187564
http://dx.doi.org/10.1155/2013/617595
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author Engel, Mark
Sidwell, Tom
Vasanthakumar, Ajithkumar
Grigoriadis, George
Banerjee, Ashish
author_facet Engel, Mark
Sidwell, Tom
Vasanthakumar, Ajithkumar
Grigoriadis, George
Banerjee, Ashish
author_sort Engel, Mark
collection PubMed
description Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.
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spelling pubmed-38031292013-11-03 Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors Engel, Mark Sidwell, Tom Vasanthakumar, Ajithkumar Grigoriadis, George Banerjee, Ashish Clin Dev Immunol Review Article Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3803129/ /pubmed/24187564 http://dx.doi.org/10.1155/2013/617595 Text en Copyright © 2013 Mark Engel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Engel, Mark
Sidwell, Tom
Vasanthakumar, Ajithkumar
Grigoriadis, George
Banerjee, Ashish
Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title_full Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title_fullStr Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title_full_unstemmed Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title_short Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
title_sort thymic regulatory t cell development: role of signalling pathways and transcription factors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803129/
https://www.ncbi.nlm.nih.gov/pubmed/24187564
http://dx.doi.org/10.1155/2013/617595
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