GKAP/SAPAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

How does chronic activity modulation lead to global remodeling of proteins at synapses and synaptic scaling? Here we report a role of guanylate-kinase-associated-protein (GKAP; also known as SAPAP), a scaffolding molecule linking NMDA receptor-PSD-95 to Shank-Homer complexes, in these processes. Ove...

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Detalles Bibliográficos
Autores principales: Shin, Seung Min, Zhang, Nanyan, Hansen, Jonathan, Gerges, Nashaat Z., Pak, Daniel T.S., Sheng, Morgan, Lee, Sang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804128/
https://www.ncbi.nlm.nih.gov/pubmed/23143515
http://dx.doi.org/10.1038/nn.3259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804128/
https://www.ncbi.nlm.nih.gov/pubmed/23143515
http://dx.doi.org/10.1038/nn.3259

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