Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive

Coronavirus replicase nsp4 is critical for virus-induced membrane modifications. An nsp4 mutant (N258T) of murine hepatitis virus (MHV) has been reported to be temperature-sensitive (ts) and to alter membrane targeting. We engineered and recovered all four possible codon variants of N258T in the clo...

Descripción completa

Detalles Bibliográficos
Autores principales: Beachboard, Dia C., Lu, Xiaotao, Baker, Susan C., Denison, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2013
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804408/
https://www.ncbi.nlm.nih.gov/pubmed/23099203
http://dx.doi.org/10.1016/j.virol.2012.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804408/
https://www.ncbi.nlm.nih.gov/pubmed/23099203
http://dx.doi.org/10.1016/j.virol.2012.10.001

Ejemplares similares