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Quantitative Analysis of α-L-Iduronidase Expression in Immunocompetent Mice Treated with the Sleeping Beauty Transposon System

The Sleeping Beauty transposon system, a non-viral, integrating vector that can deliver the alpha-L-iduronidase-encoding gene, is efficient in correcting mucopolysaccharidosis type I in NOD/SCID mice. However, in previous studies we failed to attain reliable long-term alpha-L-iduronidase expression...

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Detalles Bibliográficos
Autores principales: Aronovich, Elena L., Hall, Bryan C., Bell, Jason B., McIvor, R. Scott, Hackett, Perry B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804460/
https://www.ncbi.nlm.nih.gov/pubmed/24205141
http://dx.doi.org/10.1371/journal.pone.0078161