Cargando…

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines. The cyclic dinucleotides can be bacterial second messengers c-di-GMP and c-di-AMP, 3’5’-3’5’ cyclic GMP-AMP (3’3’ cGAMP) produced by Vibrio ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yi, Guanghui, Brendel, Volker P., Shu, Chang, Li, Pingwei, Palanathan, Satheesh, Cheng Kao, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804601/ https://www.ncbi.nlm.nih.gov/pubmed/24204993 http://dx.doi.org/10.1371/journal.pone.0077846

Ejemplares similares

Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System
por: Shu, Chang, et al.
Publicado: (2012)

STING cyclic dinucleotide sensing originated in bacteria
por: Morehouse, Benjamin R., et al.
Publicado: (2020)

STING inhibitors target the cyclic dinucleotide binding pocket
por: Hong, Ze, et al.
Publicado: (2021)

Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy
por: Shae, Daniel, et al.
Publicado: (2019)

Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy
por: Zheng, Huan, et al.
Publicado: (2022)

Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy
por: Sun, Xiaoqi, et al.
Publicado: (2021)

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing
por: Nakayama, Shizuka, et al.
Publicado: (2016)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes
por: Karanja, Caroline W., et al.
Publicado: (2020)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
por: Pollock, Alex J., et al.
Publicado: (2020)

Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
por: Leong, Meredith, et al.
Publicado: (2013)

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H
por: Walker, Melissa M., et al.
Publicado: (2020)

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein
por: Smola, Miroslav, et al.
Publicado: (2021)

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
por: Kennedy, Richard B., et al.
Publicado: (2020)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
por: Lu, Zengzeng, et al.
Publicado: (2022)

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
por: Vavřina, Zdeněk, et al.
Publicado: (2022)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity
por: Corrales, Leticia, et al.
Publicado: (2014)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

The World of Cyclic Dinucleotides in Bacterial Behavior
por: Aline Dias da, Purificação, et al.
Publicado: (2020)

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
por: Dey, Bappaditya, et al.
Publicado: (2015)

STING is a direct innate immune sensor of cyclic-di-GMP
por: Burdette, Dara L., et al.
Publicado: (2011)

Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli
por: Lv, Yun, et al.
Publicado: (2019)

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
por: Gürsoy, Ulvi K., et al.
Publicado: (2017)

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
por: Elmanfi, Samira, et al.
Publicado: (2020)

Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo
por: Annibal, Andrea, et al.
Publicado: (2021)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
por: Elmanfi, Samira, et al.
Publicado: (2018)

SLC19A1 transports immunoreactive cyclic dinucleotides
por: Luteijn, Rutger D., et al.
Publicado: (2019)

The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development
por: Yan, Hongbin, et al.
Publicado: (2021)

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c(th)GAMP
por: Veth, Simon, et al.
Publicado: (2022)

Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies
por: Van Giesen, Kyle J. D., et al.
Publicado: (2022)

APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels
por: Rieffer, Amanda E., et al.
Publicado: (2023)

Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy
por: Fu, Juan, et al.
Publicado: (2015)

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
por: Cao, Xueli, et al.
Publicado: (2023)

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
por: Li, Tiejun, et al.
Publicado: (2016)

Cyclic dinucleotides (CDNs) anti-tumors response by activating DC and NK cell crosstalk
por: Fu, Juan, et al.
Publicado: (2014)

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
por: Chang, Denis, et al.
Publicado: (2020)

The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes
por: Tiedemann, Kim, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dbg4iv1vmfm2drjn0mm5dtgasp