Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

Systematic screening based on structural similarity of drugs such as colchicine and podophyllotoxin led to identification of noscapine, a microtubule-targeted agent that attenuates the dynamic instability of microtubules without affecting the total polymer mass of microtubules. We report a new gener...

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Detalles Bibliográficos
Autores principales: Manchukonda, Naresh Kumar, Naik, Pradeep Kumar, Santoshi, Seneha, Lopus, Manu, Joseph, Silja, Sridhar, Balasubramanian, Kantevari, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804772/
https://www.ncbi.nlm.nih.gov/pubmed/24205049
http://dx.doi.org/10.1371/journal.pone.0077970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804772/
https://www.ncbi.nlm.nih.gov/pubmed/24205049
http://dx.doi.org/10.1371/journal.pone.0077970

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