Functional role of the flexible N-terminal extension of FKBP38 in catalysis

FKBP38 regulates apoptosis through unique interactions with multiple regulators including Bcl-2. Interestingly, the peptidylprolyl isomerase activity of FKBP38 is only detectable when it binds to calcium-saturated calmodulin (CaM/Ca(2+)). This, in turn, permits the formation of a complex with Bcl-2....

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Detalles Bibliográficos
Autores principales: Kang, CongBao, Ye, Hong, Chia, Joel, Choi, Bo-Hwa, Dhe-Paganon, Sirano, Simon, Bernd, Schütz, Ulrike, Sattler, Michael, Yoon, Ho Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804861/
https://www.ncbi.nlm.nih.gov/pubmed/24145868
http://dx.doi.org/10.1038/srep02985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804861/
https://www.ncbi.nlm.nih.gov/pubmed/24145868
http://dx.doi.org/10.1038/srep02985

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