Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4–CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagon...

Descripción completa

Detalles Bibliográficos
Autores principales: Devi, Sapna, Wang, Yilin, Chew, Weng Keong, Lima, Ronald, A-González, Noelia, Mattar, Citra N.Z., Chong, Shu Zhen, Schlitzer, Andreas, Bakocevic, Nadja, Chew, Samantha, Keeble, Jo L., Goh, Chi Ching, Li, Jackson L.Y., Evrard, Maximilien, Malleret, Benoit, Larbi, Anis, Renia, Laurent, Haniffa, Muzlifah, Tan, Suet Mien, Chan, Jerry K.Y., Balabanian, Karl, Nagasawa, Takashi, Bachelerie, Françoise, Hidalgo, Andrés, Ginhoux, Florent, Kubes, Paul, Ng, Lai Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804935/
https://www.ncbi.nlm.nih.gov/pubmed/24081949
http://dx.doi.org/10.1084/jem.20130056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804935/
https://www.ncbi.nlm.nih.gov/pubmed/24081949
http://dx.doi.org/10.1084/jem.20130056

Ejemplares similares