Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells

Blood cell production relies on the coordinated activities of hematopoietic stem cells (HSCs) and multipotent and lineage-restricted progenitors. Here, we identify Notchless (Nle) as a critical factor for HSC maintenance under both homeostatic and cytopenic conditions. Nle deficiency leads to a rapi...

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Detalles Bibliográficos
Autores principales: Le Bouteiller, Marie, Souilhol, Céline, Beck-Cormier, Sarah, Stedman, Aline, Burlen-Defranoux, Odile, Vandormael-Pournin, Sandrine, Bernex, Florence, Cumano, Ana, Cohen-Tannoudji, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804936/
https://www.ncbi.nlm.nih.gov/pubmed/24062412
http://dx.doi.org/10.1084/jem.20122019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804936/
https://www.ncbi.nlm.nih.gov/pubmed/24062412
http://dx.doi.org/10.1084/jem.20122019

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