Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization

The phosphatase and tumor suppressor PTEN inhibits the phosphoinositol-3-kinase (PI3K) signaling pathway and plays a key role in cell growth, proliferation, survival, and migration. Pten conditional deletion using MxCre or Scl-CreER(T) leads to splenomegaly and leukemia formation, which occurs after...

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Detalles Bibliográficos
Autores principales: Tesio, Melania, Oser, Gabriela M., Baccelli, Irène, Blanco-Bose, William, Wu, Hong, Göthert, Joachim R., Kogan, Scott C., Trumpp, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804947/
https://www.ncbi.nlm.nih.gov/pubmed/24127490
http://dx.doi.org/10.1084/jem.20122768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804947/
https://www.ncbi.nlm.nih.gov/pubmed/24127490
http://dx.doi.org/10.1084/jem.20122768

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