Complexation and Sequestration of BMP-2 from an ECM Mimetic Hyaluronan Gel for Improved Bone Formation

Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of skeletal non-union and spinal fusion. However, BMP-2 delivery in a conventional collagen scaffold necessitates a high dose to achieve an efficacious outcome. To lower its effective dose, we precomplexed BMP-...

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Detalles Bibliográficos
Autores principales: Kisiel, Marta, Klar, Agnieszka S., Ventura, Manuela, Buijs, Jos, Mafina, Marc-Krystelle, Cool, Simon M., Hilborn, Jöns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805527/
https://www.ncbi.nlm.nih.gov/pubmed/24167632
http://dx.doi.org/10.1371/journal.pone.0078551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805527/
https://www.ncbi.nlm.nih.gov/pubmed/24167632
http://dx.doi.org/10.1371/journal.pone.0078551

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