Methylglyoxal Evokes Pain by Stimulating TRPA1

Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound methylglyoxal (MG). Here we show that MG stimulates hete...

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Detalles Bibliográficos
Autores principales: Andersson, David A., Gentry, Clive, Light, Emily, Vastani, Nisha, Vallortigara, Julie, Bierhaus, Angelika, Fleming, Thomas, Bevan, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805573/
https://www.ncbi.nlm.nih.gov/pubmed/24167592
http://dx.doi.org/10.1371/journal.pone.0077986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805573/
https://www.ncbi.nlm.nih.gov/pubmed/24167592
http://dx.doi.org/10.1371/journal.pone.0077986

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