Histones-Mediated Lymphocyte Apoptosis during Sepsis Is Dependent on p38 Phosphorylation and Mitochondrial Permeability Transition

Lymphocyte apoptosis is one reason for immunoparalysis seen in sepsis, although the triggers are unknown. We hypothesized that molecules in plasma, which are up-regulated during sepsis, may be responsible for this. In this study, peripheral lymphocyte apoptosis caused by extracellular histones was c...

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Detalles Bibliográficos
Autores principales: Liu, Zhan-Guo, Ni, Shu-Yuan, Chen, Gui-Ming, Cai, Jing, Guo, Zhen-Hui, Chang, Ping, Li, Yu-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805602/
https://www.ncbi.nlm.nih.gov/pubmed/24167561
http://dx.doi.org/10.1371/journal.pone.0077131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805602/
https://www.ncbi.nlm.nih.gov/pubmed/24167561
http://dx.doi.org/10.1371/journal.pone.0077131

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