Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype

Background: Non-homologous end joining (NHEJ) is the main repair pathway for DNA double strand breaks (DSBs) induced by ionizing radiation in mammalian cells. Subsets of cancer patients are hypersensitive to radiotherapy after standard doses. We sought to determine the radiosensitivity of human lymp...

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Detalles Bibliográficos
Autores principales: Yap, Seow Fong, Boo, Cynthia SK, Loong, Susan LE, Baskar, Rajamanickam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805988/
https://www.ncbi.nlm.nih.gov/pubmed/24155772
http://dx.doi.org/10.7150/jca.6453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805988/
https://www.ncbi.nlm.nih.gov/pubmed/24155772
http://dx.doi.org/10.7150/jca.6453

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