Cyclodextrin Formulation of the Marine Natural Product Pseudopterosin A Uncovers Optimal Pharmacodynamics in Proliferation Studies of Human Umbilical Vein Endothelial Cells

Pseudopterosin A (PsA) treatment of growth factor depleted human umbilical vein endothelial cell (HUVEC) cultures formulated in hydroxypropyl-β-cyclodextrin (HPβCD) for 42 h unexpectedly produced a 25% increase in cell proliferation (EC(50) = 1.34 × 10(−8) M). Analysis of dose response curves reveal...

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Detalles Bibliográficos
Autores principales: Day, Daniel R., Jabaiah, Suraya, Jacobs, Robert S., Little, R. Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806459/
https://www.ncbi.nlm.nih.gov/pubmed/24065164
http://dx.doi.org/10.3390/md11093258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806459/
https://www.ncbi.nlm.nih.gov/pubmed/24065164
http://dx.doi.org/10.3390/md11093258

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