Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC(50) 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant strain) (IC(50) 3.3 μM) while exhibiting low leve...

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Detalles Bibliográficos
Autores principales: Lam, Cary F. C., Pearce, A. Norrie, Tan, Shen H., Kaiser, Marcel, Copp, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806465/
https://www.ncbi.nlm.nih.gov/pubmed/24022732
http://dx.doi.org/10.3390/md11093472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806465/
https://www.ncbi.nlm.nih.gov/pubmed/24022732
http://dx.doi.org/10.3390/md11093472

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