Cargando…
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC(50) 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant strain) (IC(50) 3.3 μM) while exhibiting low leve...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806465/ https://www.ncbi.nlm.nih.gov/pubmed/24022732 http://dx.doi.org/10.3390/md11093472 |