Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors

In this study, we report on pyrazin-2(1H)-ones as lead for the development of potent adenosine triphosphate (ATP) competitive protein kinase inhibitors with implications as anti-cancer drugs. Initially, we identified the pyrazin-2(1H)-one scaffold from hamacanthins (deep sea marine sponge alkaloids)...

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Detalles Bibliográficos
Autores principales: Pinchuk, Boris, Johannes, Eugen, Gul, Sheraz, Schlosser, Joachim, Schaechtele, Christoph, Totzke, Frank, Peifer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806475/
https://www.ncbi.nlm.nih.gov/pubmed/24065162
http://dx.doi.org/10.3390/md11093209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806475/
https://www.ncbi.nlm.nih.gov/pubmed/24065162
http://dx.doi.org/10.3390/md11093209

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