Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), b...

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Detalles Bibliográficos
Autores principales: Chianese, Giuseppina, Scala, Fernando, Calcinai, Barbara, Cerrano, Carlo, Dien, Henny A., Kaiser, Marcel, Tasdemir, Deniz, Taglialatela-Scafati, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806476/
https://www.ncbi.nlm.nih.gov/pubmed/23989650
http://dx.doi.org/10.3390/md11093297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806476/
https://www.ncbi.nlm.nih.gov/pubmed/23989650
http://dx.doi.org/10.3390/md11093297

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