β-Cell–Specific IL-2 Therapy Increases Islet Foxp3(+)Treg and Suppresses Type 1 Diabetes in NOD Mice

Interleukin-2 (IL-2) is a critical cytokine for the homeostasis and function of forkhead box p3–expressing regulatory T cells (Foxp3(+)Tregs). Dysregulation of the IL-2–IL-2 receptor axis is associated with aberrant Foxp3(+)Tregs and T cell–mediated autoimmune diseases such as type 1 diabetes. Treat...

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Detalles Bibliográficos
Autores principales: Johnson, Mark C., Garland, Alaina L., Nicolson, Sarah C., Li, Chengwen, Samulski, R. Jude, Wang, Bo, Tisch, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806588/
https://www.ncbi.nlm.nih.gov/pubmed/23884888
http://dx.doi.org/10.2337/db13-0669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806588/
https://www.ncbi.nlm.nih.gov/pubmed/23884888
http://dx.doi.org/10.2337/db13-0669

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