Cargando…

β-Cell–Specific IL-2 Therapy Increases Islet Foxp3(+)Treg and Suppresses Type 1 Diabetes in NOD Mice

Interleukin-2 (IL-2) is a critical cytokine for the homeostasis and function of forkhead box p3–expressing regulatory T cells (Foxp3(+)Tregs). Dysregulation of the IL-2–IL-2 receptor axis is associated with aberrant Foxp3(+)Tregs and T cell–mediated autoimmune diseases such as type 1 diabetes. Treat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Mark C., Garland, Alaina L., Nicolson, Sarah C., Li, Chengwen, Samulski, R. Jude, Wang, Bo, Tisch, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806588/ https://www.ncbi.nlm.nih.gov/pubmed/23884888 http://dx.doi.org/10.2337/db13-0669

Ejemplares similares

Autoreactive Effector/Memory CD4(+) and CD8(+) T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage
por: Diz, Ramiro, et al.
Publicado: (2012)

Foxp3 Post-translational Modifications and Treg Suppressive Activity
por: Deng, Guoping, et al.
Publicado: (2019)

IL-35 promotes CD4(+)Foxp3(+) Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms
por: Shao, Ying, et al.
Publicado: (2021)

Treatment of Intestinal Inflammation With Epicutaneous Immunotherapy Requires TGF-β and IL-10 but Not Foxp3(+) Tregs
por: Chen, Xin, et al.
Publicado: (2021)

Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice
por: He, Xinran, et al.
Publicado: (2020)

IL-34 Actions on FOXP3(+) Tregs and CD14(+) Monocytes Control Human Graft Rejection
por: Bézie, Séverine, et al.
Publicado: (2020)

Endothelial Cells Activated by Extracellular Histones Promote Foxp3(+) Suppressive Treg Cells In Vitro
por: Arnaud, Marine, et al.
Publicado: (2022)

Changes in Natural Foxp3(+)Treg but Not Mucosally-Imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the Circulation of Celiac Disease Patients
por: van Leeuwen, Marieke A., et al.
Publicado: (2013)

Mesenchymal Stem Cell Induced Foxp3(+) Tregs Suppress Effector T Cells and Protect against Retinal Ischemic Injury
por: Agrawal, Mona, et al.
Publicado: (2021)

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine
por: Harrison, OJ, et al.
Publicado: (2015)

Co-Expression of FOXP3FL and FOXP3Δ2 Isoforms Is Required for Optimal Treg-Like Cell Phenotypes and Suppressive Function
por: Sato, Yohei, et al.
Publicado: (2021)

Induction of stable human FOXP3(+) Tregs by a parasite‐derived TGF‐β mimic
por: Cook, Laura, et al.
Publicado: (2021)

Th1-Like ICOS(+) Foxp3(+) T(reg) Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice
por: Kornete, Mara, et al.
Publicado: (2015)

CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation
por: Jones, Mark B., et al.
Publicado: (2019)

The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function
por: Prakhar, Praveen, et al.
Publicado: (2021)

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans
por: Janson, Peter C. J., et al.
Publicado: (2008)

Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3(+) Treg Cells
por: Layland, Laura E., et al.
Publicado: (2013)

CTLA-4 Modulates the Differentiation of Inducible Foxp3(+) Treg Cells but IL-10 Mediates Their Function in Experimental Autoimmune Encephalomyelitis
por: Verhagen, Johan, et al.
Publicado: (2014)

Cancer-FOXP3 directly activated CCL5 to recruit FOXP3(+)Treg cells in pancreatic ductal adenocarcinoma
por: Wang, X, et al.
Publicado: (2017)

FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
por: Nie, Jia, et al.
Publicado: (2015)

Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis
por: Deliyanti, Devy, et al.
Publicado: (2017)

Foxp3 Molecular Dynamics in Treg in Juvenile Idiopathic Arthritis
por: Copland, Alastair, et al.
Publicado: (2018)

Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6
por: Saini, Chaman, et al.
Publicado: (2016)

The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
por: Ghosh, Sayantani, et al.
Publicado: (2018)

The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3(+) Treg Cells
por: Waickman, Adam T., et al.
Publicado: (2020)

Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype
por: O’Hagan, Kyle L., et al.
Publicado: (2017)

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
por: Akirav, Eitan M., et al.
Publicado: (2011)

Stability and Maintenance of Foxp3(+) Treg Cells in Non-lymphoid Microenvironments
por: Korn, Thomas, et al.
Publicado: (2019)

Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications
por: Dong, Yi, et al.
Publicado: (2021)

Enriched circulating and tumor-resident TGF-β(+) regulatory B cells in patients with melanoma promote FOXP3(+) Tregs
por: Harris, Robert J, et al.
Publicado: (2022)

Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo
por: Ludvigsen, Eva, et al.
Publicado: (2011)

Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3(+) Treg Cells by Multiparameter Flow Cytometry
por: Li, Can, et al.
Publicado: (2020)

IL‐34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis
por: Freuchet, Antoine, et al.
Publicado: (2022)

HTLV-1 epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional proliferative suppression of Tregs
por: Anderson, Monique R, et al.
Publicado: (2014)

Human‐engineered Treg‐like cells suppress FOXP3‐deficient T cells but preserve adaptive immune responses in vivo
por: Sato, Yohei, et al.
Publicado: (2020)

Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3(+) Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
por: Abo, Hirohito, et al.
Publicado: (2019)

Tregs and Mixed Chimerism as Approaches for Tolerance Induction in Islet Transplantation
por: Pathak, Shiva, et al.
Publicado: (2021)

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
por: Schmidt, Angelika, et al.
Publicado: (2018)

Prediction of Adeno-Associated Virus Neutralizing Antibody Activity for Clinical Application
por: Wang, Mei, et al.
Publicado: (2015)

Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3(+) Treg cells
por: Verhagen, Johan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ru7h315oe0d923nt03ros00qbt